Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …

Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to
thousands copies in cells depending on cell metabolism and exposure to endogenous …

Background: Lung cancer is the leading cause of cancer-related death worldwide, of which
lung adenocarcinoma (LUAD) is one of the main histological subtypes. Mitochondria are …

Mitochondrial impairment and increased oxidative stress are common features in
neurodegenerative disorders, leading researchers to speculate that epigenetic changes in …

In recent years, the number of studies dedicated to ascertaining the connection between
mitochondria and cancer has significantly risen. However, more efforts are still needed to …

Mitochondria are major organelles involved in several processes related to energy supply,
metabolism, and cell proliferation. The mitochondria function is transcriptionally regulated by …

Dysregulation of mitochondrial function often precedes malignant transformation of
hematopoietic stem cells (HSCs). Mitochondria have a direct role in the maintenance of HSC …

ABSTRACT AIM: To determine the mitochondrial microsatellite instability (mtMSI) status in a
series of Malaysian patients with brain tumors. Furthermore, we analyzed whether the mtMSI …

Deregulated mitochondrial metabolism and biogenesis have been studied in acute myeloid
leukemia (AML); yet, the relevance of mitochondrial-encoded gene expression on AML …

The role of mitochondrial DNA (mt-DNA) changes, especially those in the regulatory D-loop
region in Acute Myeloid Leukemia (AML) remains investigational. Consecutive 151 de novo …