Alzheimer's disease is of major concern all over the world due to a number of factors
including (i) an aging population (ii) increasing life span and (iii) lack of effective …

Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …

This review summarizes recent reports on s-triazine and its respective analogs from the
medicinal chemistry angle. Due to its high reactivity and binding characteristic towards …

Through drug discovery strategies of repurposing and redeveloping existing drugs, a series
of novel tadalafil derivatives were rationally designed, synthesized, and evaluated to seek …

A novel electrochemical immunosensor fabricated from gold compact disc electrodes was
designed for rapid evaluation of aggregation processes that lead to the formation of …

A series of coumarin derivatives were designed, synthesized, and evaluated as novel
multifunctional agents against Alzheimer's disease (AD). In vitro studies showed that most of …

Notwithstanding the functional role that the aggregates of some amyloidogenic proteins can
play in different organisms, protein aggregation plays a pivotal role in the pathogenesis of a …

The multifaceted nature of Alzheimer's disease (AD) demands treatment with multitarget-
directed ligands (MTDLs) to confront the key pathological aberrations. A novel series of …

Multi target directed ligands (MTDLs) are one of the promising tools for treatment of complex
disease like Alzheimer's disease (AD). In this study, using rational design, we synthesized …

Few effective therapies exist for the treatment of neurodegenerative diseases that have been
characterized as protein misfolding disorders. Upregulation of heat shock proteins (Hsps) …