Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

Cytoplasmic dynein is a microtubule motor that is activated by its cofactor dynactin and a
coiled-coil cargo adaptor,–. Up to two dynein dimers can be recruited per dynactin, and …

Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence
of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to …

Cytoplasmic dynein is a molecular motor that transports a large variety of cargoes (eg,
organelles, messenger RNAs, and viruses) along microtubules over long intracellular …

The multiple functions of lysosomes are critically dependent on their ability to undergo
bidirectional movement along microtubules between the center and the periphery of the cell …

Highlights•Endolysosomal organelles are dynamically distributed throughout the
cytoplasm.•Movement of endolysosomal organelles depends on coupling to microtubule …

The endocytic pathway is essential for processes that define how cells interact with their
environment, including receptor signalling, cell adhesion and migration, pathogen entry …

ABSTRACT Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that
drives the movement of diverse cargos along the microtubule cytoskeleton, including …

Intracellular trafficking pathways, including endocytosis, autophagy, and secretion, rely on
directed organelle transport driven by the opposing microtubule motor proteins kinesin and …