Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …

Amino acid availability controls mTORC1 activity via a heterodimeric Rag GTPase complex
that functions as a scaffold at the lysosomal surface, bringing together mTORC1 with its …

Abstract Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations,
resulting in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) …

The glycoprotein nonmetastatic melanoma protein B (GPNMB, also known as osteoactivin)
is highly expressed in many cell types and regulates the homeostasis in various tissues. In …

Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is
a rare type of kidney cancer, which is not well characterized. Here we show the …

Translocation renal cell carcinoma (tRCC) is a poorly characterized subtype of kidney
cancer driven by MiT/TFE gene fusions. Here, we define the landmarks of tRCC through an …

TFE3-translocation renal cell carcinoma (TFE3-tRCC) is a rare and heterogeneous subtype
of kidney cancer with no standard treatment for advanced disease. We describe …

Translocation renal cell carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3
fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we …

Abstract Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome
characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and …