What can we learn from rodents about prolactin in humans?

N Ben-Jonathan, CR LaPensee… - Endocrine …, 2008 - academic.oup.com
Abstract Prolactin (PRL) is a 23-kDa protein hormone that binds to a single-span membrane
receptor, a member of the cytokine receptor superfamily, and exerts its action via several …

Osteoporosis, genetics and hormones

R Rizzoli, JP Bonjour, SL Ferrari - Journal of molecular …, 2001 - jme.bioscientifica.com
Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

Peptide hormone regulation of angiogenesis

C Clapp, S Thebault, MC Jeziorski… - Physiological …, 2009 - journals.physiology.org
It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …

A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer

SS Tworoger, AH Eliassen, P Sluss… - Journal of Clinical …, 2007 - ascopubs.org
Purpose Epidemiologic studies suggest that prolactin is associated with breast cancer risk in
older women. Because of limited prospective data, particularly in younger women, we …

The RNA-binding protein Sam68 is a multifunctional player in human cancer

P Bielli, R Busà, MP Paronetto… - Endocrine-related …, 2011 - erc.bioscientifica.com
Resistance to chemotherapy is a major complication in the treatment of advanced breast
cancer. Estrogens and prolactin (PRL) are implicated in the pathogenesis of breast cancer …

Development and potential clinical uses of human prolactin receptor antagonists

V Goffin, S Bernichtein, P Touraine… - Endocrine …, 2005 - academic.oup.com
There is a large body of literature showing that prolactin (PRL) exerts growth-promoting
activities in breast cancer, and possibly in prostate cancer and prostate hyperplasia. In …

Prolactin and breast cancer etiology: an epidemiologic perspective

SS Tworoger, SE Hankinson - Journal of mammary gland biology and …, 2008 - Springer
A number of epidemiologic studies of prolactin and breast cancer etiology have recently
become available. Retrospective case-control studies have suggested a modest positive or …

Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle …

K Foitzik, K Krause, F Conrad, M Nakamura… - The American journal of …, 2006 - Elsevier
The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects
in mammals and is also found in extrapituitary sites, including murine skin. Here, we show …

Relationship between prolactin, breast cancer risk, and antipsychotics in patients with schizophrenia: a critical review

M De Hert, J Peuskens, T Sabbe… - Acta Psychiatrica …, 2016 - Wiley Online Library
Objective A recent meta‐analysis showed that breast cancer probably is more common in
female patients with schizophrenia than in the general population (effect size= 1.25, P< …

Prolactin and breast cancer risk

SS Tworoger, SE Hankinson - Cancer letters, 2006 - Elsevier
Prolactin, a hormone involved in normal breast development and lactation, has been
hypothesized to be important in the etiology of breast cancer. This review summarizes in …