Intracellular Effects of Lithium in Aging Neurons

JA Godoy, RG Mira, NC Inestrosa - Ageing Research Reviews, 2024 - Elsevier
Lithium therapy received approval during the 1970s, and it has been used for its
antidepressant, antimanic, and anti-suicidal effects for acute and long-term prophylaxis and …

Lithium and its effects: does dose matter?

M Manchia, P Paribello, M Pinna, L Steardo Jr… - International journal of …, 2024 - Springer
Background Decades of clinical research have demonstrated the efficacy of lithium in
treating acute episodes (both manic and depressive), as well as in preventing recurrences of …

[HTML][HTML] Promising Effects of Novel Supplement Formulas in Preventing Skin Aging in 3D Human Keratinocytes

A Punzo, M Perillo, A Silla, M Malaguti, S Hrelia… - Nutrients, 2024 - mdpi.com
Dietary intervention is considered a safe preventive strategy to slow down aging. This study
aimed to evaluate the protective effects of a commercially available supplement and six …

Low-dose lithium adjunct to atypical antipsychotic treatment nearly improved cognitive impairment, deteriorated the gray-matter volume, and decreased the interleukin …

C Zhuo, S Hu, G Chen, L Yang, Z Cai, H Tian, D Jiang… - Schizophrenia, 2023 - nature.com
This study was conducted to investigate the effects of long-term low-dose lithium adjunct to
antipsychotic agent use on the cognitive performance, whole-brain gray-matter volume …

[HTML][HTML] More than a number: Incorporating the aged phenotype to improve in vitro and in vivo modeling of neurodegenerative disease

LM Carr, S Mustafa, A Care… - Brain, Behavior, and …, 2024 - Elsevier
Age is the number one risk factor for developing a neurodegenerative disease (ND), such as
Alzheimer's disease (AD) or Parkinson's disease (PD). With our rapidly ageing world …

Beneficial effects of walnut oligopeptides on muscle loss in senescence-accelerated mouse Prone-8 (SAMP8) mice: focusing on mitochondrial function

R Fan, Y Hao, Q Du, J Kang, M Xu, Y Li - Nutrients, 2022 - mdpi.com
Aging-related muscle loss is a hallmark of aging and is the cause of some negative
outcomes. An optimized diet and supplements have a positive effect in slowing down the …

Microdose lithium improves behavioral deficits and modulates molecular mechanisms of memory formation in female SAMP-8, a mouse model of accelerated aging

AAR Pereira, AM Pinto, HN Malerba, M Toricelli… - Plos one, 2024 - journals.plos.org
Alzheimer's disease (AD) is the most common neuronal disorder that leads to the
development of dementia. Until nowadays, some therapies may alleviate the symptoms, but …

Combined neuroprotective strategies blocked neurodegeneration and improved brain function in senescence-accelerated mice

HN Malerba, AAR Pereira, MF Pierrobon… - Frontiers in Aging …, 2021 - frontiersin.org
Increase in the quality of life, combined with drug strategies, has been studied as
possibilities for improving memory and delaying the onset of neurodegenerative diseases. A …

Low-dose lithium mono-and adjunctive therapies improve MK-801-induced cognitive impairment and schizophrenia-like behavior in mice-Evidence from altered …

C Zhuo, H Tian, G Chen, J Ping, L Yang, C Li… - Journal of Affective …, 2023 - Elsevier
Background Few studies have evaluated lithium either as monotherapy or in combination
with anti-psychotic agents to improve cognition in murine models of schizophrenia. Methods …

[HTML][HTML] Trace Lithium for Suicide Prevention and Dementia Prevention: A Qualitative Review

T Terao, H Hirakawa, M Muronaga, T Izumi… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Anti-manic effects of lithium and the nature of trace element in lithium were first
observed in 1949. In this review, we explore the potential effects of trace lithium in the …