Efr3b is essential for social recognition by modulating the excitability of CA2 pyramidal neurons

X Wei, J Wang, E Yang, Y Zhang… - Proceedings of the …, 2024 - National Acad Sciences
CA2 pyramidal neurons (PNs) are associated with social behaviors. The mechanisms,
however, remain to be fully investigated. Here, we report that Efr3b, a protein essential for …

Reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal CA2 region in a mouse model of temporal lobe epilepsy

AC Whitebirch, B Santoro, A Barnett… - Journal of …, 2023 - Soc Neuroscience
A significant proportion of temporal lobe epilepsy (TLE) patients experience drug-resistant
seizures associated with mesial temporal sclerosis, in which there is extensive cell loss in …

[HTML][HTML] Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely moving macaques

S Abbaspoor, KL Hoffman - Cell Reports, 2024 - cell.com
Diverse neuron classes in hippocampal CA1 have been identified through the heterogeneity
of their cellular/molecular composition. How these classes relate to hippocampal function …

The prosubiculum in the human hippocampus: A rostrocaudal, feature‐driven, and systematic approach

EW Rosenblum, EM Williams… - Journal of …, 2024 - Wiley Online Library
The hippocampal subfield prosubiculum (ProS), is a conserved neuroanatomic region in
mouse, monkey, and human. This area lies between CA1 and subiculum (Sub) and …

Introduction to the special issue on: A new view of hippocampal area CA2.

SM Dudek, GM Alexander, S Farris - Hippocampus, 2023 - search.ebscohost.com
Both drawings are of tissue from mice. gl As yet, no molecular marker has been identified
that clearly distinguishes between the CA2 neurons receiving mossy fibers, and those in …

[PDF][PDF] GABA fluctuations driven by astrocytic Glu/GABA exchange explain synaptic acuity

L Héja, J Kardos - Cell Signal, 2023 - probiologists.com
Abbreviations: Bestrophin 1: Homopentameric Ca2+-activated Cl− channel; EAAT2
(SLC1A2, GLT-1): Excitatory Amino Acid Transporter type 2 to Glu uptake in astrocytes by …

Social odors drive hippocampal CA2 place cell responses to social stimuli

E Robson, MM Donahue, AJ Mably, PG Demetrovich… - bioRxiv, 2024 - biorxiv.org
Hippocampal region CA2 is essential for social memory processing. Interaction with social
stimuli induces changes in CA2 place cell firing during active exploration and sharp wave …

Input/Output Relationships for the Primary Hippocampal Circuit.

BG Gunn, BS Pruess, CM Gall, G Lynch - bioRxiv, 2023 - biorxiv.org
The hippocampus is likely the most studied brain region but little is known about signal
throughput--the simplest, yet most essential of circuit operations--across its multiple stages …

Excitatory neurons in stratum radiatum provide an alternative pathway for excitation flow that escapes perisomatic inhibition

J Lebedeva, DJ Jappy, A Nasretdinov, A Vazetdinova… - bioRxiv, 2023 - biorxiv.org
For over half a century, it has been postulated that the internal excitatory circuit in the
hippocampus consists of three relay stations. Excitation arrives from the entorhinal cortex to …

Hippocampal circuit dynamics during learning and sleep in freely behaving macaque monkeys

S Abbaspoor - 2024 - ir.vanderbilt.edu
The ability of organisms to learn and form memories based on experience and to use these
memories flexibly in different situations is a hallmark of cognitive evolutionary processes …