Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

The transcriptional upregulation of oncogenes is a driving force behind the progression of
many tumours. However, until a decade ago, the concept of 'switching off'these oncogenic …

Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Protein–protein interactions (PPIs) are of pivotal importance in the regulation of biological
systems and are consequently implicated in the development of disease states. Recent work …

The past 20 years have seen many advances in our understanding of protein-protein
interactions (PPIs) and how to target them with small-molecule therapeutics. In 2004, we …

Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities.
Developing compounds with heterocycle rings has been one of the trends. The integration of …

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant
acetylation levels have been linked to the development of several diseases. Acetyl-lysine …

The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3,
BRD4, and testis-specific BRDT members, are epigenetic “readers” and play a key role in …

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic
options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results …