Navigating the chiral pool in the total synthesis of complex terpene natural products

ZG Brill, ML Condakes, CP Ting, TJ Maimone - Chemical reviews, 2017 - ACS Publications
The pool of abundant chiral terpene building blocks (ie,“chiral pool terpenes”) has long
served as a starting point for the chemical synthesis of complex natural products, including …

A brief history of antibiotics and select advances in their synthesis

KC Nicolaou, S Rigol - The Journal of antibiotics, 2018 - nature.com
The advent of modern antibiotics contributed enormously to the dramatic extension of
human lifespan since their discovery by virtue of their lethal and selective action against …

Predictive model for oxidative C–H bond functionalization reactivity with 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone

CA Morales-Rivera, PE Floreancig… - Journal of the American …, 2017 - ACS Publications
2, 3-Dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ) is a highly effective reagent for
promoting C–H bond functionalization. The oxidative cleavage of benzylic and allylic C–H …

Asymmetric Synthesis and Biological Evaluation of Platensilin, Platensimycin, Platencin, and Their Analogs via a Bioinspired Skeletal Reconstruction Approach

ZX Gao, H Wang, AH Su, QY Li, Z Liang… - Journal of the …, 2024 - ACS Publications
Platensilin, platensimycin, and platencin are potent inhibitors of β-ketoacyl–acyl carrier
protein synthase (FabF) in the bacterial and mammalian fatty acid synthesis system …

Mechanism‐Based Approach to Reagent Selection for Oxidative Carbon− Hydrogen Bond Cleavage Reactions

JL Miller, L Zhou, P Liu… - Chemistry–A European …, 2022 - Wiley Online Library
Numerous hydride‐abstracting agents generate the same cationic intermediate, but
substrate features such as intermediate cation stability, oxidation potential, and steric …

Potassium tert-Butoxide-Mediated Condensation Cascade Reaction: Transition Metal-Free Synthesis of Multisubstituted Aryl Indoles and Benzofurans

P Yang, W Xu, R Wang, M Zhang, C Xie, X Zeng… - Organic …, 2019 - ACS Publications
An efficient and facile method to synthesize valuable disubstituted 2-aryl indoles and
benzofurans in good yields has been demonstrated, based on a tert-butoxide-mediated …

Recent advances on the total synthesis of alkaloids in mainland China

Y Li, J Li, H Ding, A Li - National Science Review, 2017 - academic.oup.com
Alkaloids are a large family of natural products that mostly contain basic nitrogen atoms.
Because of their intriguing structures and important functions, they have long been popular …

Diversity‐Oriented Synthesis of Carbohydrate Scaffolds through the Prins Cyclization of Differently Protected d‐Mannitol‐Derived Homoallylic Alcohols

S Dubbu, YD Vankar - European Journal of Organic Chemistry, 2017 - Wiley Online Library
A diversity‐oriented synthesis of a variety of carbohydrate scaffolds, including sugar‐fused
isochroman derivatives, bicyclic vinyl halide derivatives, fluorine‐substituted …

Copper-catalyzed highly diastereoselective cross-dehydrogenative coupling between 8-hydroxyisochromanes and 1, 3-dicarbonyl compounds

Z Zhang, YQ Tu, XM Zhang, FM Zhang… - Organic Chemistry …, 2019 - pubs.rsc.org
Herein, a novel copper-catalyzed highly diastereoselective cross-dehydrogenative coupling
reaction is reported. A broad range of 1, 3-dicarbonyl compounds and 8 …

Short Enantioselective Formal Synthesis of (–)-Platencin

C Defieber, JT Mohr, GA Grabovyi, BM Stoltz - Synthesis, 2018 - thieme-connect.com
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