This review provides the latest developments and trends in the application of fractional
calculus (FC) in biomedicine and biology. Nature has often showed to follow rather simple …

Fractals have been very successful in quantifying nature's geometrical complexity, and have
captured the imagination of scientific community. The development of fractal dimension and …

Background. Descriptions of the pharmacokinetics and metabolism of morphine and its
metabolites in young children are scant. Previous studies have not differentiated the effects …

The volume of distribution (VD) in humans of 179 known drug molecules (acids, bases, and
neutrals) has been modeled using two biomimetic-binding measurements. The phospholipid …

Although, no credible data are available, it is widely believed that the pharmacokinetic
parameters such as clearance, volume of distribution, and elimination half-life can be scaled …

Tumors cannot grow beyond a certain size (about 1–2 mm in diameter) through simple
diffusion of oxygen and other essential nutrients into the tumor. Angiogenesis, the formation …

Pharmacokinetics (PK) has been traditionally dealt with under the homogeneity assumption.
However, biological systems are nowadays comprehensively understood as being …

Three advanced models of pharmacokinetics are described. In the first class are
physiologically based pharmacokinetic models based on in vitro data on transport and …

Objective To study morphine pharmacokinetics in neonates undergoing venoarterial ECMO
and to quantify differences between these neonates and neonates subjected to noncardiac …

The development of medium to high‐throughput in vitro screening of ADME (Absorption,
Distribution, Metabolism, Excretion) properties has been the reply to higher demands on …