Antibodies and antibody derivatives constitute 20% of biopharmaceutical products currently
in development, and despite early failures of murine products, chimeric and humanized …

Enormous efforts have been made to produce a protective vaccine against human
immunodeficiency virus type 1; there has been little success. However, the identification of …

Random peptide libraries and antigen-fragment libraries (also known as gene-fragment
libraries) have been used to identify epitopes on protein antigens. These technologies …

The book provides a comprehensive view of the impact and promise of phage display in
drug discovery and biotechnology. Building on the success of its previous edition, the book …

Over the past year, significant advances have been achieved through the use of phage-
displayed peptide libraries. A wide variety of bioactive molecules, including antibodies …

Monoclonal antibodies are one of the most successful bio-molecules utilized in the clinical
scene of today. It is important to clarify general characteristics of the interaction between …

In camelids, a subset of the immunoglobulins consists of heavy-chain homodimers devoid of
light chains, and are thus called heavy-chain IgGs (hcIgGs). Their variable region (VHH) is …

Antigen mimicry by anti‐idiotypic antibodies is investigated as a reliable strategy to achieve
molecular imprinting of an enzymatic activity. A monoclonal anti‐idiotypic antibody (Ab2 …

Mimotopes mimic the three‐dimensional topology of an antigen epitope, and are frequently
recognized by antibodies with affinities comparable to those obtained for the original …

The clinical development of therapeutic proteins requires assays that measure the
pharmacokinetic (PK) profile of, and the potential immune response (IR) to, the protein …