Various human diseases can disrupt the balance between muscle contraction and
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …

The heart pumps blood to maintain circulation and ensure the delivery of oxygenated blood
to all the organs of the body. Mechanics play a critical role in governing and regulating heart …

Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …

Background Left ventricular (LV) wall stress reduction is a cornerstone in treating heart
failure. Large animal models and computer simulations indicate that adding non-contractile …

Predictive computational modeling has revolutionized classical engineering disciplines and
is in the process of transforming cardiovascular research. This is particularly relevant for …

Individually personalized computational models of heart mechanics can be used to estimate
important physiological and clinically‐relevant quantities that are difficult, if not impossible …

In the present study, we investigated the optimal material properties of a tunable hydrogel for
the treatment of myocardial infarction (MI) along with the therapeutic mechanism. We …

Although computational modeling is common in many areas of science and engineering,
only recently have advances in experimental techniques and medical imaging allowed this …

This study measured how heart failure affects the contractile properties of the human
myocardium from the left and right ventricles. The data showed that maximum force and …

Injection of Algisyl-LVR, a treatment under clinical development, is intended to treat patients
with dilated cardiomyopathy. This treatment was recently used for the first time in patients …