Machine-learning techniques for the prediction of protein–protein interactions
Protein–protein interactions (PPIs) are important for the study of protein functions and
pathways involved in different biological processes, as well as for understanding the cause …
pathways involved in different biological processes, as well as for understanding the cause …
[HTML][HTML] How different viruses perturb host cellular machinery via short linear motifs
The virus interacts with its hosts by developing protein-protein interactions. Most viruses
employ protein interactions to imitate the host protein: A viral protein with the same amino …
employ protein interactions to imitate the host protein: A viral protein with the same amino …
Rapidly evolving viral motifs mostly target biophysically constrained binding pockets of host proteins
Evolutionary changes in host-virus interactions can alter the course of infection, but the
biophysical and regulatory constraints that shape interface evolution remain largely …
biophysical and regulatory constraints that shape interface evolution remain largely …
High-throughput methods for identification of protein-protein interactions involving short linear motifs
C Blikstad, Y Ivarsson - Cell Communication and Signaling, 2015 - Springer
Interactions between modular domains and short linear motifs (3–10 amino acids peptide
stretches) are crucial for cell signaling. The motifs typically reside in the disordered regions …
stretches) are crucial for cell signaling. The motifs typically reside in the disordered regions …
Short linear motifs in colorectal cancer interactome and tumorigenesis
C Fasano, V Grossi, G Forte, C Simone - Cells, 2022 - mdpi.com
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for
cancer initiation, progression, and invasion. This multistage process is based on a dense …
cancer initiation, progression, and invasion. This multistage process is based on a dense …
Prediction of virus-host protein-protein interactions mediated by short linear motifs
Background Short linear motifs in host organisms proteins can be mimicked by viruses to
create protein-protein interactions that disable or control metabolic pathways. Given that …
create protein-protein interactions that disable or control metabolic pathways. Given that …
PPI-Miner: A Structure and Sequence Motif Co-Driven Protein–Protein Interaction Mining and Modeling Computational Method
Protein–protein interactions (PPIs) play important roles in biological processes of life, and
predicting PPIs becomes a critical scientific issue of concern. Most PPIs occur through small …
predicting PPIs becomes a critical scientific issue of concern. Most PPIs occur through small …
The present and the future of motif-mediated protein–protein interactions
Highlights•Motif-mediated interactions play key roles in essential cellular processes.•Due to
distinctive properties of motifs—short, disordered and small interfaces—detection of them …
distinctive properties of motifs—short, disordered and small interfaces—detection of them …
Uncovering domain motif interactions using high‐throughput protein–protein interaction detection methods
Protein–protein interactions (PPIs) are often mediated by short linear motifs (SLiMs) in one
protein and domain in another, known as domain–motif interactions (DMIs). During the past …
protein and domain in another, known as domain–motif interactions (DMIs). During the past …
SLiMEnrich: computational assessment of protein–protein interaction data as a source of domain-motif interactions
Many important cellular processes involve protein–protein interactions (PPIs) mediated by a
Short Linear Motif (SLiM) in one protein interacting with a globular domain in another …
Short Linear Motif (SLiM) in one protein interacting with a globular domain in another …