Lineage tracing meets single-cell omics: opportunities and challenges
A fundamental goal of developmental and stem cell biology is to map the developmental
history (ontogeny) of differentiated cell types. Recent advances in high-throughput single …
history (ontogeny) of differentiated cell types. Recent advances in high-throughput single …
Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
A human cell atlas of fetal gene expression
INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
[HTML][HTML] Fumarate induces vesicular release of mtDNA to drive innate immunity
V Zecchini, V Paupe, I Herranz-Montoya, J Janssen… - Nature, 2023 - nature.com
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …
An atlas of healthy and injured cell states and niches in the human kidney
Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …
associated molecular profiles and interactions within tissue neighbourhoods. Here we …
Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response
Diverse subtypes of renal cell carcinomas (RCCs) display a wide spectrum of
histomorphologies, proteogenomic alterations, immune cell infiltration patterns, and clinical …
histomorphologies, proteogenomic alterations, immune cell infiltration patterns, and clinical …
[PDF][PDF] Single-cell transcriptome atlas of murine endothelial cells
The heterogeneity of endothelial cells (ECs) across tissues remains incompletely
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
Studying tissue composition and function in non-human primates (NHPs) is crucial to
understand the nature of our own species. Here we present a large-scale cell transcriptomic …
understand the nature of our own species. Here we present a large-scale cell transcriptomic …
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
Y Kirita, H Wu, K Uchimura… - Proceedings of the …, 2020 - National Acad Sciences
After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …