The nuclear Overhauser enhancement or effect (NOE) is the most important measure in
liquid-state NMR with macromolecules. Thus, the NOE is the subject of numerous reviews …

Around half of all protein structures solved nowadays using solution-state nuclear magnetic
resonance (NMR) spectroscopy have been because of automated data analysis. The …

Proton-driven 13C spin diffusion (PDSD) is a simple and robust two-dimensional NMR
experiment. It leads to spectra with a high signal-to-noise ratio in which cross-peaks contain …

Magic-angle spinning (MAS) solid-state NMR becomes an increasingly important tool for the
determination of structures of membrane proteins and amyloid fibrils. Extensive deuteration …

The ParB protein forms DNA bridging interactions around parS to condense DNA and
earmark the bacterial chromosome for segregation. The molecular mechanism underlying …

Aggregation and misfolding of the prion protein (PrP) are thought to be the cause of a family
of lethal neurodegenerative diseases affecting humans and other animals. Although the …

In solution or solid-state, determining the three-dimensional structure of biomolecules by
Nuclear Magnetic Resonance (NMR) normally requires the collection of distance …

G protein-coupled receptors (GPCRs) are key players in signal recognition and cell
communication and are among the most important targets for drug development. Direct …

Acetylation is correlated with chromatin decondensation and transcriptional activation, but its
regulation by histone deacetylase (HDAC)-bearing corepressor complexes is poorly …

We have recently developed an NMR protocol to extract exact distances between nuclei in
proteins from an exact interpretation of NOESY buildup intensities (eNOEs). This enabled us …