Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

The generation of mitochondrial superoxide (O 2−·) by reverse electron transport (RET) at
complex I causes oxidative damage in pathologies such as ischemia reperfusion injury, but …

Protein-protein interactions govern almost all cellular functions. These complex networks of
stable and transient associations can be mapped by affinity purification mass spectrometry …

Coenzyme Q (CoQ, ubiquinone) is the electron‐carrying lipid in the mitochondrial electron
transport system (ETS). In mammals, it serves as the electron acceptor for nine mitochondrial …

Mitochondrial respiratory supercomplexes, comprising complexes I, III, and IV, are the
minimal functional units of the electron transport chain. Assembling the individual complexes …

Mitochondrial reactive oxygen species (ROS) can be either detrimental or beneficial
depending on the amount, duration, and location of their production. Mitochondrial complex I …

Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring
electrons from coenzyme Q directly to O 2. They have therefore been proposed as a …

Electron transfer from all respiratory chain dehydrogenases of the electron transport chain
(ETC) converges at the level of the quinone (Q) pool. The Q redox state is thus a function of …