Coronavirus porcine epidemic diarrhea virus (PEDV) is classified in the genus
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …

Coronaviruses (CoVs) are enveloped and positive-stranded RNA viruses with a large
genome (∼ 30kb). CoVs include essential genes, such as the replicase and four genes …

Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary
camels and causes zoonotic infection and disease in humans. Although over 80% of the …

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) open reading frame 9b
(ORF9b) antagonizes the antiviral type I and III interferon (IFN) responses and is …

Abstract Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-
2 infection. Patients with severe COVID-19 exhibit robust induction of proinflammatory …

Within the past 2 decades, three highly pathogenic human coronaviruses have emerged,
namely, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East …

Targeted protein degradation is a new aspect in the field of drug discovery. Traditionally,
developing an antibiotic includes tedious and expensive processes, such as drug screening …

The ORF9b protein, derived from the nucleocapsid's open-reading frame in both SARS-CoV
and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by …

Coronaviruses employ various strategies for survival, among which the activation of
endogenous or exogenous apoptosis stands out, with viral proteins playing a pivotal role …

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is continuously
producing new variants, necessitating effective therapeutics. Patients are not only …