Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver
cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC …

Conclusion: HBV-induced HCC is a complex, stepwise process that includes integration of
HBV DNA into host DNA at multiple or single sites. On the contrary, the cancerogenesis …

Kuper H, Adami H‐O & Trichopoulos D (Harvard School of Public Health, Boston, MA, USA;
Karolinska Institute, Stockholm, Sweden; University of Athens Medical School, Greece) …

Hepatitis C virus (HCV) is the main cause of chronic hepatitis worldwide. Chronic hepatitis
ultimately results in the development of hepatocellular carcinoma 1, 2 (HCC). However, the …

Risk factors associated with hepatocellular carcinoma (HCC) are well documented, but the
synergisms between these risk factors are not well examined. We conducted a hospital …

Background & Aims: The mechanisms of liver injury in chronic hepatitis C virus (HCV)
infection are poorly understood. Indirect evidence suggests that oxidative stress and …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

The PKR protein kinase is a critical component of the cellular antiviral and antiproliferative
responses induced by interferons. Recent evidence indicates that the nonstructural 5A …

Hepatitis C virus (HCV) infection is now recognized to be a major risk factor for
hepatocellular carcinoma (HCC), evidenced by finding both antibody to HCV (anti-HCV) and …

Hepatitis C was first recognized as a distinct form of liver disease in the mid-1970s with the
advent of diagnostic tests for hepatitis A and B virus infection (A LTER et al. 1975; P RINCE …