Aldehyde dehydrogenase 2 (ALDH2) has both dehydrogenase and esterase activity; its
dehydrogenase activity is closely related to the metabolism of aldehydes produced under …

Drug repurposing is an attractive, pragmatic approach to drug discovery that has yielded
success across medical fields over the years. The use of existing medicines for novel …

Disulfiram (DSF) is a well-known anti-alcohol agent that inhibits aldehyde dehydrogenase
and results in extreme 'hangover'symptoms when consumed with alcohol. This drug …

Methamphetamine (MA), a potent central nervous system stimulant, mainly affects the brain
dopaminergic and serotoninergic systems. Monoamine oxidase, catechol-O …

Obesity is one of the most common global health problems for all age groups with obese
people at risk of a variety of associated health complications. Consequently, there is a need …

Cancer is a major global health issue. Effective therapeutic strategies can prolong patients'
survival and reduce the costs of treatment. Drug repurposing, which identifies new …

Introduction Glioblastoma (GB) is one of the most challenging central nervous system (CNS)
tumors in treatment options and response, urging the development of novel management …

Background: Adipogenesis, glycosaminoglycan hyaluronan (HA) production, inflammation,
and fibrosis are the main pathogenic mechanisms responsible for Graves' orbitopathy (GO) …

Obesity, diabetes, and other metabolic disorders place a huge burden on both the physical
health and financial well-being of the community. While the need for effective treatment of …

Introduction Hypoglycemia is listed as an adverse effect in the package inserts of not only
hypoglycemic agents but also many other drugs. We aimed to clarify real-world factors …