The human digestive tract contains a diverse and abundant microbiota that is important for
health. Excessive alcohol use can disrupt the balance of these microbes (known as …

Alcohol use disorder (AUD) is characterized by excessive habitual drinking and loss of
control over alcohol intake despite negative consequences. Both of these aspects foster …

Compulsive alcohol consumption is a core, treatment-resistant feature of alcohol use
disorder. The dorsomedial and dorsolateral striatum support goal-directed and habitual …

Goal-directed behavior often requires the inhibition of prepotent automatic responses.
Response inhibition encompasses several top-down cognitive operations embedded in a …

Background Many people with harmful addictive behaviors may not meet formal diagnostic
thresholds for a disorder. A dimensional approach, by contrast, including clinical and …

Despite the catastrophic consequences of alcohol abuse, alcohol use disorders (AUD) and
comorbidities continue to strain the healthcare system, largely due to the effects of alcohol …

Value based choice and compulsion theories of addiction offer distinct explanations for the
persistence of alcohol use despite harms. Choice theory argues that problematic drinkers …

(a) Objective This study aimed to identify trajectories of alcohol use (AU) and their
associations with the development of alcohol use disorder (AUD) among young men with …

Background Though compulsive drinking is a hallmark of alcohol use disorder (AUD), little is
known of the neural mechanisms driving this behavior. To further the understanding of the …

Alcohol use, which alters the epigenome, increases the probability that it could affect
subsequent generations, even if they were never directly exposed to ethanol or even in …