Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Integrin adhesion receptors are essential for the normal function of most multicellular
organisms, and defective integrin activation or integrin signaling is associated with an array …

Integrins are heterodimeric transmembrane receptors for extracellular matrix (ECM)
components and they link the intracellular actin cytoskeleton to the cellular environment …

The myotendinous junction (MTJ) is a complex specialized region located at the muscle-
tendon interface that represents the primary site of force transmission. Despite their different …

In C. elegans, mutants that are defective in muscle function and/or structure are easy to
detect and analyze since: 1) body wall muscle is essential for locomotion, and 2) muscle …

Cell-extracellular matrix interactions have been studied extensively using cells cultured in
vitro. These studies indicate that focal adhesion (FA)-based cell-extracellular matrix …

Cells in developing organisms are subjected to particular mechanical forces that shape
tissues and instruct cell fate decisions. How these forces are sensed and transmitted at the …

Cell-matrix adhesion is essential for building animals, promoting tissue cohesion, and
enabling cells to migrate and resist mechanical force. Talin is an intracellular protein that is …

Presynaptic homeostatic plasticity (PHP) adaptively regulates synaptic transmission in
health and disease. Despite identification of numerous genes that are essential for PHP, we …