Glioblastoma multiforme is the most lethal intrinsic brain tumor. Even with the existing
treatment regimen of surgery, radiation, and chemotherapy, the median survival time is only …

The blood–brain barrier (BBB) is a protective element of the neurovascular unit (NVU)
surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex …

Immunotherapy with toll like receptor 9 (TLR9) agonist CpG ODN offers an emergent
strategy to treat life‐threatening malignant glioma. CpG is typically applied invasively by …

Injections of highly cytotoxic or immunomodulating drugs directly into the inoperable tumor is
a procedure that is increasingly applied in the clinic and uses established Pt-based drugs. It …

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated
metabolism in GBM offers an opportunity to deploy metabolic interventions as precise …

Glioma is the most common primary intracranial malignancy in the central nervous system.
At present, the most important treatment option is surgical resection of the tumor combined …

Despite remarkable recent progress in developing anti-cancer agents, outcomes of patients
with solid tumors remain unsatisfactory. In general, anti-cancer drugs are systemically …

Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic
pontine glioma-DIPG), is the primary cause of brain tumor-related death in pediatric patients …

Glioblastoma multiforme (GBM) is considered to be one of the most devastating brain tumors
with a shorter life expectancy. Several factors contribute to the dismal prognosis of GBM …

Purpose: Antibody-drug conjugates (ADC) are targeted therapies with robust efficacy in solid
cancers, and there is intense interest in using EGFR-specific ADCs to target EGFR-amplified …