Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex
with its prodomain. Activation of TGF-β1 requires the binding of αv integrin to an RGD …

Integrins dynamically equilibrate between three conformational states on cell surfaces. A
bent conformation has a closed headpiece. Two extended conformations contain either a …

In the present study, we re-annotated von Willebrand factor (VWF), assigned its entire
sequence to specific modules, and related these modules to structure using electron …

Lycium barbarum is widely used as a functional food and medicinal herb to promote health
and longevity in China and in some other Asian countries. In modern pharmacological and …

The activation of leukocyte integrins through diverse receptors results in transformation of
the integrin from a bent, resting form to an extended conformation, which has at least two …

T cells defend against cancer and viral infections by rapidly scanning the surface of target
cells seeking specific peptide antigens. This key process in adaptive immunity is sparked …

Recognition of laminin by integrin receptors is central to the epithelial cell adhesion to
basement membrane, but the structural background of this molecular interaction remained …

For a cell to move forward it must convert chemical energy into mechanical propulsion.
Force produced by actin polymerization can generate traction across the plasma membrane …