Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

RM de Jong, SK Tebeje… - Immunological …, 2020 - Wiley Online Library
The efficient spread of malaria from infected humans to mosquitoes is a major challenge for
malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to …

Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants

SR Bonam, L Rénia, G Tadepalli, J Bayry, HMS Kumar - Vaccines, 2021 - mdpi.com
Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

Plasmodium vivax vaccine: What is the best way to go?

GTS Veiga, MR Moriggi, JF Vettorazzi… - Frontiers in …, 2023 - frontiersin.org
Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax

N Kunkeaw, W Nguitragool, E Takashima… - npj Vaccines, 2023 - nature.com
Plasmodium vivax (P. vivax) is the major malaria parasite outside of Africa and no vaccine is
available against it. A vaccine that interrupts parasite transmission (transmission-blocking …

Potent AMA1-specific human monoclonal antibody against Plasmodium vivax Pre-erythrocytic and Blood Stages

AC Winnicki, MH Dietrich, LM Yeoh, LL Carias… - Nature …, 2024 - nature.com
New therapeutics are necessary for preventing Plasmodium vivax malaria due to easy
transmissibility and dormancy in the liver that increases the clinical burden due to recurrent …

Systems biology of malaria explored with nonhuman primates

MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …

Progress towards the development of a P. vivax vaccine

SL De, FB Ntumngia, J Nicholas… - Expert review of …, 2021 - Taylor & Francis
Introduction Plasmodium vivax causes significant public health problems in endemic
regions. A vaccine to prevent disease is critical, considering the rapid spread of drug …

Mathematical models of Plasmodium vivax transmission: A scoping review

MN Anwar, L Smith, A Devine, S Mehra… - PLOS Computational …, 2024 - journals.plos.org
Plasmodium vivax is one of the most geographically widespread malaria parasites in the
world, primarily found across South-East Asia, Latin America, and parts of Africa. One of the …

Increased interferon-γ levels and risk of severe malaria: a meta-analysis

A Mahittikorn, W Mala, FR Masangkay, KU Kotepui… - Scientific reports, 2022 - nature.com
Interferon (IFN)-γ contributes to the pathogenesis of severe malaria; however, its mechanism
remains unclear. Herein, differences in IFN-γ levels between patients with severe and …

[HTML][HTML] Plasmodium vivax transmission-blocking vaccines: Progress, challenges and innovation

M Tachibana, E Takashima, M Morita… - Parasitology …, 2022 - Elsevier
Existing control measures have significantly reduced malaria morbidity and mortality in the
last two decades, although these reductions are now stalling. Significant efforts have been …