Breast cancer is a genetically and clinically heterogeneous disease with multiple subtypes.
The classification of these subtypes has evolved over the years. The most common and …

The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …

Ferroptosis is a novel type of cell death with distinct properties and recognizing functions
involved in physical conditions or various diseases including cancers. The fast-growing …

Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous
free radical whose predominant functions is that of a messenger through cGMP. In …

Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and
are implicated in epithelial to mesenchymal transition, cell-cycle progression …

Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

The dominant paradigm in drug discovery is to design ligands with maximum selectivity to
act on individual drug targets. With the target-based approach, many new chemical entities …

Cholesterol is a risk factor for breast cancer although the mechanisms by which this occurs
are not well understood. One hypothesis is that dyslipidemia results in increased cholesterol …

Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic
intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper …