Lineage tracing meets single-cell omics: opportunities and challenges

DE Wagner, AM Klein - Nature Reviews Genetics, 2020 - nature.com
A fundamental goal of developmental and stem cell biology is to map the developmental
history (ontogeny) of differentiated cell types. Recent advances in high-throughput single …

A community-based transcriptomics classification and nomenclature of neocortical cell types

R Yuste, M Hawrylycz, N Aalling, A Aguilar-Valles… - Nature …, 2020 - nature.com
To understand the function of cortical circuits, it is necessary to catalog their cellular
diversity. Past attempts to do so using anatomical, physiological or molecular features of …

[HTML][HTML] Molecular topography of an entire nervous system

SR Taylor, G Santpere, A Weinreb, A Barrett, MB Reilly… - Cell, 2021 - cell.com
We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

Construction of a cross-species cell landscape at single-cell level

R Wang, P Zhang, J Wang, L Ma, WE… - Nucleic acids …, 2023 - academic.oup.com
Individual cells are basic units of life. Despite extensive efforts to characterize the cellular
heterogeneity of different organisms, cross-species comparisons of landscape dynamics …

A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity

S Levy, A Elek, X Grau-Bové, S Menéndez-Bravo… - Cell, 2021 - cell.com
Stony corals are colonial cnidarians that sustain the most biodiverse marine ecosystems on
Earth: coral reefs. Despite their ecological importance, little is known about the cell types …

Single-cell resolution of lineage trajectories in the Arabidopsis stomatal lineage and developing leaf

CB Lopez-Anido, A Vatén, NK Smoot, N Sharma… - Developmental cell, 2021 - cell.com
Dynamic cell identities underlie flexible developmental programs. The stomatal lineage in
the Arabidopsis leaf epidermis features asynchronous and indeterminate divisions that can …

Mapping single-cell atlases throughout Metazoa unravels cell type evolution

AJ Tarashansky, JM Musser, M Khariton, P Li, D Arendt… - Elife, 2021 - elifesciences.org
Comparing single-cell transcriptomic atlases from diverse organisms can elucidate the
origins of cellular diversity and assist the annotation of new cell atlases. Yet, comparison …

[HTML][HTML] Single-cell transcriptomics identifies conserved regulators of neuroglandular lineages

J Steger, AG Cole, A Denner, T Lebedeva… - Cell Reports, 2022 - cell.com
Communication in bilaterian nervous systems is mediated by electrical and secreted signals;
however, the evolutionary origin and relation of neurons to other secretory cell types has not …

Planted Graphene Quantum Dots for Targeted, Enhanced Tumor Imaging and Long‐Term Visualization of Local Pharmacokinetics

H Yan, Q Wang, J Wang, W Shang, Z Xiong… - Advanced …, 2023 - Wiley Online Library
While photoluminescent graphene quantum dots (GQDs) have long been considered very
suitable for bioimaging owing to their protein‐like size, superhigh photostability and in vivo …

Systematic identification of cell-fate regulatory programs using a single-cell atlas of mouse development

L Fei, H Chen, L Ma, WE, R Wang, X Fang, Z Zhou… - Nature Genetics, 2022 - nature.com
Waddington's epigenetic landscape is a metaphor frequently used to illustrate cell
differentiation. Recent advances in single-cell genomics are altering our understanding of …