Significant research efforts are ongoing to elucidate the complex molecular mechanisms
underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential …

A significant amount of RNA is present in the nucleus of mammalian cells but only a small
proportion of it is destined for the cytoplasm and subsequent translation, leaving much RNA …

Summary Cys2-His2 zinc-finger proteins (C2H2-ZNFs) constitute the largest class of DNA-
binding transcription factors (TFs) yet remain largely uncharacterized. Although certain …

RNA–protein interaction networks govern many biological processes but are difficult to
examine comprehensively. We devised ribonucleoprotein networks analyzed by mutational …

Precise control of gene expression during differentiation relies on the interplay of chromatin
and nuclear structure. Despite an established contribution of nuclear membrane proteins to …

Abnormalities in nucleic acid processing are associated with the development of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin …

Nuclear depletion of TDP-43, an essential RNA binding protein, may underlie
neurodegeneration in amyotrophic lateral sclerosis (ALS). As several functions have been …

Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration
and an important therapeutic target. Our current understanding of TDP-43 …

Abstract A missense mutation, S85C, in the MATR3 gene is a genetic cause for amyotrophic
lateral sclerosis (ALS). It is unclear how the S85C mutation affects MATR3 function and …

Background Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative
disease characterized by progressive loss of upper and lower motor neurons. While …