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Recent findings broadened the function of RNA polymerase II (Pol II) proximal promoter
motifs from quantitative regulators of transcription to important determinants of transcription …

Unstable transcripts have emerged as markers of active enhancers in vertebrates and
shown to be involved in many cellular processes and medical disorders. However, their …

Despite extensive characterization of mammalian Pol II transcription, the DNA sequence
determinants of transcription initiation at a third of human promoters and most enhancers …

Pteroceltis tatarinowii, a unique single-species plant and fibrous tree in China, is the raw
material for making Xuan paper. However, the lack of a complete genome sequence has …

Human stem cell-derived models have emerged as an important platform to study tissue
differentiation and disease mechanisms. Those models could capitalize on biochemical and …

Abstract Background Next-Generation Sequencing (NGS) catalyzed breakthroughs across
various scientific domains. Illumina's sequencing by synthesis method has long been central …

During the last decade, artificial intelligence (AI) was applied to nearly all domains of human
activity, including scientific research. It is thus warranted to ask whether AI thinking should …

Glucagon has recently been found to modulate liver fat content, in addition to its role in
regulating gluconeogenesis. However, the precise mechanisms by which glucagon …

Research on long non-coding RNAs (lncRNAs) has garnered significant attention due to
their critical roles in gene regulation and disease mechanisms. However, the complexity and …