Branched-chain amino acid biosynthesis in fungi
Branched-chain amino acids (BCAAs)—isoleucine, leucine, and valine—are synthesized by
fungi. These amino acids are important components of proteins and secondary metabolites …
fungi. These amino acids are important components of proteins and secondary metabolites …
[HTML][HTML] Comparison of healthy and dandruff scalp microbiome reveals the role of commensals in scalp health
Several scalp microbiome studies from different populations have revealed the association
of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp …
of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp …
[HTML][HTML] Molecular targets for antifungals in amino acid and protein biosynthetic pathways
A Kuplińska, K Rząd - Amino Acids, 2021 - Springer
Fungi cause death of over 1.5 million people every year, while cutaneous mycoses are
among the most common infections in the world. Mycoses vary greatly in severity, there are …
among the most common infections in the world. Mycoses vary greatly in severity, there are …
[HTML][HTML] The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus
N Long, T Orasch, S Zhang, L Gao, X Xu… - PLoS …, 2018 - journals.plos.org
Both branched-chain amino acids (BCAA) and iron are essential nutrients for eukaryotic
cells. Previously, the Zn2Cys6-type transcription factor Leu3/LeuB was shown to play a …
cells. Previously, the Zn2Cys6-type transcription factor Leu3/LeuB was shown to play a …
Leucine biosynthesis is required for infection-related morphogenesis and pathogenicity in the rice blast fungus Magnaporthe oryzae
Y Que, X Yue, N Yang, Z Xu, S Tang, C Wang, W Lv… - Current Genetics, 2020 - Springer
The rice blast fungus Magnaporthe oryzae causes one of the most devastating crop
diseases world-wide and new control strategies for blast disease are urgently required. We …
diseases world-wide and new control strategies for blast disease are urgently required. We …
The novel J-domain protein Mrj1 is required for mitochondrial respiration and virulence in Cryptococcus neoformans
The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian
environment to establish an infection. Proteins facilitating adaptation to novel environments …
environment to establish an infection. Proteins facilitating adaptation to novel environments …
The ZIP family zinc transporters support the virulence of Cryptococcus neoformans
Zinc is an essential element in living organisms and a cofactor for various metalloproteins.
To disseminate and survive, a pathogenic microbe must obtain zinc from the host, which is …
To disseminate and survive, a pathogenic microbe must obtain zinc from the host, which is …
Exposure of Candida parapsilosis to the silver(I) compound SBC3 induces alterations in the proteome and reduced virulence
M Piatek, C O'Beirne, Z Beato, M Tacke… - Metallomics, 2022 - academic.oup.com
The antimicrobial properties of silver have been exploited for many centuries and continue
to gain interest in the fight against antimicrobial drug resistance. The broad-spectrum activity …
to gain interest in the fight against antimicrobial drug resistance. The broad-spectrum activity …
The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in Aspergillus fumigatus
In contrast to mammalia, fungi are able to synthesize the branched-chain amino acid leucine
de novo. Recently, the transcription factor LeuB has been shown to cross-regulate leucine …
de novo. Recently, the transcription factor LeuB has been shown to cross-regulate leucine …
播期和种植密度对青贮玉米生产性能和饲用品质的影响
游永亮， 李源， 赵海明， 武瑞鑫， 李建明， 刘贵波… - 草地 …, 2021 - manu40.magtech.com.cn
金属离子参与真菌和哺乳动物众多重要的生长代谢过程. 隐球菌利用金属离子参与毒力因子的
形成; 宿主利用金属离子进行自身代谢, 增强机体免疫, 抵御隐球菌感染. 因此深入研究隐球菌 …
形成; 宿主利用金属离子进行自身代谢, 增强机体免疫, 抵御隐球菌感染. 因此深入研究隐球菌 …