Dendrimers are highly branched polymers with easily modifiable surfaces. This makes them
promising structures for functionalization and also for conjugation with drugs and DNA/RNA …

Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can
mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano …

Advances in nanotechnology have had profound impacts on therapeutic delivery, leading to
the development of nanomaterials engineered with large carrying capabilities and targeting …

The therapeutic and diagnostic effects of nanoparticles highly depend on the efficiency of
their delivery to targeted tissues, such as tumors. The size of nanoparticles, among other …

Although much progress has been made in treating cancers, cancer death rates in and
around the United States are still high. Current treatments are either ineffective against some …

Nanoscale drug delivery systems for cancer treatment have demonstrated promising results
in enhancing the selectivity of therapeutic agents while reducing their toxic side effects …

Nanoparticle (NP)-based drug delivery platforms have received a great deal of attention
over the past two decades for their potential in targeted cancer therapies. Despite the …

An enormous effort has been put into designing nanoparticles (NPs) with controlled
biodistributions, prolonged plasma circulation times, and/or enhanced tissue targeting …

Effective targeting drug delivery system for glioma treatment is still greatly challenged by the
existence of the blood–brain barrier (BBB) and the intracranial overspreading of anti-tumor …

Covalent modification of a drug with a peptide moiety has been extensively used as an
effective strategy to improve the drug's therapeutic outcome. One important consideration in …