Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Olfactory receptors are G protein-coupled receptors that mediate olfactory chemosensation
and serve as chemosensors in other tissues. We find that Olfr78, an olfactory receptor …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Background: The renin angiotensin system (RAS) plays an important role in inflammation
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …

Infections of the respiratory tract are more frequent in the winter months and especially in the
northern latitudes than they are in summer [1]. This obviously also applies to the COVID-19 …

The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …

Inappropriate activation of the renin-angiotensin system, which plays a central role in the
regulation of blood pressure, electrolyte, and volume homeostasis, may represent a major …

Abstract Background and Objectives Angiotensin-converting enzyme 2 (ACE2) converts
angiotensin II (Ang1-8) to angiotensin 1-7 (Ang1-7), a functional antagonist of Ang1-8, with …

Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …