Neutrophils have been historically associated with antimicrobial functions in acute infections
but are now appreciated as functionally versatile cells with critical roles in chronic …

Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

Resolution of inflammation is essential for tissue homeostasis and represents a promising
approach to inflammatory disorders. Here we found that developmental endothelial locus-1 …

The mammalian hematopoietic system is remarkably efficient in meeting an organism's vital
needs, yet is highly sensitive and exquisitely regulated. Much of the organismal control over …

Hematopoietic stem cells (HSC) reside in the bone marrow (BM) within a specialized micro-
environment, the HSC niche, which comprises several cellular constituents. These include …

The causative role of inflammation in hypertension-related cardiovascular diseases is
evident and calls for development of specific immunomodulatory therapies. We tested the …

In contrast to traditional immune cell-centered viewpoints, recent studies suggest that tissues
are not passive recipients of immunity but have a 'regulatory say'over the host inflammatory …

An intact and fully functional innate immune system is critical in the defense against
pathogens. Indeed, during systemic infection, the ability of the organism to cope with the …

The regulation of oxygen (O2) levels is crucial in embryogenesis and adult life, as O2
controls a multitude of key cellular functions. Low oxygen levels (hypoxia) are relevant for …

The secreted protein developmental endothelial locus 1 (DEL-1) regulates inflammatory cell
recruitment and protects against inflammatory pathologies in animal models. Here, we …