Exosomes and exosomal miRNA in respiratory diseases

SD Alipoor, E Mortaz, J Garssen… - Mediators of …, 2016 - Wiley Online Library
Exosomes are nanosized vesicles released from every cell in the body including those in the
respiratory tract and lungs. They are found in most body fluids and contain a number of …

Exosomes: a new horizon in modern medicine

A Deb, S Gupta, PB Mazumder - Life Sciences, 2021 - Elsevier
Exosomes are a type of extracellular vesicles belonging to endocytic origin. These vesicles
carry different biological cargo that play numerous physiological roles and is also indicative …

Distinct exosomal miRNA profiles from BALF and lung tissue of COPD and IPF patients

G Kaur, KP Maremanda, M Campos, HS Chand… - International journal of …, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are
chronic, progressive lung ailments that are characterized by distinct pathologies. Early …

Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis

D Lacedonia, G Scioscia, P Soccio, M Conese… - BMC pulmonary …, 2021 - Springer
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a degenerative interstitial lung
disease with both a poor prognosis and quality of life once the diagnosis is made. In the last …

Roles of exosomes in cardiac fibroblast activation and fibrosis

J Hohn, W Tan, A Carver, H Barrett, W Carver - Cells, 2021 - mdpi.com
Alterations in the accumulation and composition of the extracellular matrix are part of the
normal tissue repair process. During fibrosis, this process becomes dysregulated and …

Composition and clinical significance of exosomes in tuberculosis: a systematic literature review

F Biadglegne, B König, AC Rodloff, A Dorhoi… - Journal of Clinical …, 2021 - mdpi.com
Tuberculosis (TB) remains a major health issue worldwide. In order to contain TB infections,
improved vaccines as well as accurate and reliable diagnostic tools are desirable …

Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo

S Elliot, P Catanuto, S Pereira-Simon, X Xia… - Elife, 2022 - elifesciences.org
Background: MicroRNAs (miRNA) and other components contained in extracellular vesicles
may reflect the presence of a disease. Lung tissue, sputum, and sera of individuals with …

Current and prospective applications of exosomal microRNAs in pulmonary fibrosis

T Yang, J Wang, J Zhao, Y Liu - … Journal of Molecular …, 2022 - spandidos-publications.com
Pulmonary fibrosis (PF) is a chronic, progressive, irreversible and life‑threatening lung
disease. However, the pathogenesis and molecular mechanisms of this condition remain …

Diagnostic and therapeutic applications of extracellular vesicles in interstitial lung diseases

A Ibrahim, A Ibrahim, T Parimon - Diagnostics, 2021 - mdpi.com
Interstitial lung diseases (ILDs) are chronic irreversible pulmonary conditions with significant
morbidity and mortality. Diagnostic approaches to ILDs are complex and multifactorial …

The Influence of Extracellular RNA on Cell Behavior in Health, Disease, and Regeneration

L Huleihel, ME Scarritt, SF Badylak - Current pathobiology reports, 2017 - Springer
Abstract Purpose of Review An overview of the role of extracellular RNAs (exRNA) in the
regulation of homeostasis, disease progression, and regeneration is provided herein …