There is increasing evidence in some malignancies that the tumor clone is heterogeneous in
regard to proliferation and differentiation. The cancer stem cell hypothesis implies that not all …

Although stem cell therapy holds tremendous promise in tissue regeneration and disease
treatment, its full potential may only be realized through the thorough understanding and …

The interaction between cells and the extracellular matrix (ECM) is essential during
development. To elucidate the function of ECM proteins on cell differentiation, we developed …

To identify a viable cell source with potential neuroprotective effects, we studied amnion-
derived multipotent progenitor (AMP) cells in a rat model of penetrating ballistic-like brain …

Background Neurogenesis, the production of neural cell-types from neural stem cells
(NSCs), occurs during development as well as within select regions of the adult brain. NSCs …

In native tissue, cell-secreted extracellular molecules form the supporting extracellular matrix
(ECM) to the cells that provides structural and biochemical signals to the cells. Natural ECM …

Nanofibrous matrices serve as artificial substrates to partially mimic the key physical and
structural characteristics of the stem cell niche. Three methods for the preparation of …

The advantage of nanomaterials in the biomedical field can be explored through the use of
nanofibers designed using biocompatible and biodegradable polymers. Owing to their …

The microenvironment plays an integral role in directing the differentiation of stem cells. The
ability to control and manipulate systems on the microscale can be used to control the …

A central issue in stem cell biology is the determination of function and activity of
differentiated stem cells, features that define the true phenotype of mature cell types …