[HTML][HTML] Sarcopenia associated with chemotherapy and targeted agents for cancer therapy

MP Davis, R Panikkar - Annals of palliative medicine, 2019 - apm.amegroups.org
Clinicians often believe that cachexia is caused by cancer and anorexia as a toxicity of
chemotherapy or targeted anti-cancer agents. It is now recognized that chemotherapy and …

Myosteatosis in cirrhosis: a review of diagnosis, pathophysiological mechanisms and potential interventions

M Ebadi, C Tsien, RA Bhanji, AR Dunichand-Hoedl… - Cells, 2022 - mdpi.com
Myosteatosis, or pathological excess fat accumulation in muscle, has been widely defined
as a lower mean skeletal muscle radiodensity on computed tomography (CT). It is reported …

Cancer cachexia is defined by an ongoing loss of skeletal muscle mass

VE Baracos, VC Mazurak… - Annals of palliative …, 2019 - apm.amegroups.org
Since 2007, a quantitative, specific and precise approach to the detection of muscle loss has
become accessible with the advent of image-based assessments. Computed tomography …

Chemotherapy-induced sarcopenia

F Bozzetti - Current treatment options in oncology, 2020 - Springer
Opinion statement Sarcopenia is being consistently recognized as a condition not only
associated with the presence of a malignancy but also induced by the oncologic therapies …

Cancer cachexia and skeletal muscle atrophy in clinical studies: what do we really know?

A Dolly, JF Dumas, S Servais - Journal of Cachexia …, 2020 - Wiley Online Library
Research investigators have shown a growing interest in investigating alterations underlying
skeletal muscle wasting in patients with cancer. However, skeletal muscle dysfunctions …

Microbiota-host-irinotecan axis: a new insight toward irinotecan chemotherapy

B Yue, R Gao, Z Wang, W Dou - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Irinotecan (CPT11) and its active metabolite ethyl-10-hydroxy-camptothecin (SN38) are
broad-spectrum cytotoxic anticancer agents. Both cause cell death in rapidly dividing cells …

prognostic significance of body composition abnormalities in patients with cirrhosis

M Ebadi, RA Bhanji, P Tandon… - Alimentary …, 2020 - Wiley Online Library
Background Recent advances in evaluation of body composition show body mass index to
be inadequate in differentiating between body compartments in cirrhosis. Given the …

Chemotherapy-induced myopathy: the dark side of the cachexia sphere

DG Campelj, CA Goodman, E Rybalka - Cancers, 2021 - mdpi.com
Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …

A window beneath the skin: how computed tomography assessment of body composition can assist in the identification of hidden wasting conditions in oncology that …

LE Daly, CM Prado, AM Ryan - Proceedings of the Nutrition Society, 2018 - cambridge.org
Advancements in image-based technologies and body composition research over the past
decade has led to increased understanding of the importance of muscle abnormalities, such …

Assessing skeletal muscle radiodensity by computed tomography: an integrative review of the applied methodologies

TS Poltronieri, NS de Paula… - Clinical Physiology and …, 2020 - Wiley Online Library
Low‐radiodensity skeletal muscle has been related to the degree of muscle fat infiltration
and seems to be associated with worse outcomes. The aim of this study was to summarize …