Transforming growth factor beta (TGFβ) is a pleiotropic cytokine that plays a key role in both
physiologic and pathologic conditions, including cancer. Importantly, TGFβ can exhibit both …

Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

Background High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by
extensive inter-and intratumour heterogeneity, resulting in persistent therapeutic resistance …

Epithelial‐mesenchymal transition (EMT) is a reversible and dynamic process hypothesized
to be co‐opted by carcinoma during invasion and metastasis. Yet, there is still no …

The platinum derivative cis-diamminedichloroplatinum (II), best known as cisplatin, is
currently employed for the clinical management of patients affected by testicular, ovarian …

Ovarian cancer (OC) remains a fatal malignancy because most patients experience
recurrent disease, which is resistant to chemotherapy. The outcomes for patients with …

Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …

The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for
tumor growth and progression. Cells of both the innate and adaptive immune system, in …

Ovarian cancer has poor survival rates due to a combination of diagnosis at advanced
disease stages and disease recurrence as a result of platinum chemotherapy resistance …

Following a period of slow progress, the completion of genome sequencing and the
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …