Integrative modeling is an increasingly important tool in structural biology, providing
structures by combining data from varied experimental methods and prior information. As a …

Understanding the effects of genetic variation is a fundamental problem in biology that
requires methods to analyse both physical and functional consequences of sequence …

Interplay between chromatin-associated complexes and modifications critically contribute to
the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack …

Biological systems are by nature multiscale, consisting of subsystems that factor into
progressively smaller units in a deeply hierarchical structure. At any level of the hierarchy …

Integrative structural modeling enables structure determination of macromolecules and their
complexes by integrating data from multiple sources. It has been successfully used to …

We adopted a novel strategy by combining histone deacetylase (HDAC) inhibitors with
traditional chemotherapeutics to treat solid tumors. However, chemotherapeutics often have …

Molecular switch proteins whose cycling between states is controlled by opposing
regulators, are central to biological signal transduction. As switch proteins function within …

There is a growing interest in characterizing the structure and dynamics of large
biomolecular assemblies and their interactions within the cellular environment. A diverse …

Assembly pathways of protein complexes should be precise and efficient to minimise
misfolding and unwanted interactions with other proteins in the cell. One way to achieve this …

Since genome sequencing became accessible, determining how specific differences in
genotypes lead to complex phenotypes such as disease has become one of the key goals in …