Parkinson disease is a progressive neurological condition characterised by hypokinesia
(reduced movement), akinesia (absent movement), tremor, rigidity and postural instability …

Abstract SURGICAL OPTIONS FOR Parkinson's disease (PD) are rapidly expanding and
include ablative procedures, deep brain stimulation, and cell transplantation. The target …

Pharmacologic treatment for essential tremor and the tremor of Parkinson's disease is often
inadequate. Stereotaxic surgery, such as thalamotomy, can effectively reduce tremors. We …

Background Posteroventral medial pallidotomy sometimes produces striking improvement in
patients with advanced Parkinson's disease, but the studies to date have involved small …

Object. The authors describe the microelectrode recording and stimulation techniques used
for localizing the caudal sensorimotor portion of the globus pallidus internus (GPi) and …

Thirty‐six patients with Parkinson's disease (PD) were randomized to either medical therapy
(N= 18) or unilateral GPi pallidotomy (N= 18). The primary outcome variable was the change …

We studied the effects—on parkinsonian signs, on levodopa‐induced dyskinesias, and on
levodopa response—of acute experimental high‐frequency stimulation of the internal …

Object. The aim of this study was to evaluate the long-term safety and efficacy of bilateral
contemporaneous deep brain stimulation (DBS) in patients who have levodopa-responsive …

OBJECTIVE: To optimize the accuracy of initial stereotactic targeting for movement disorders
surgery, we performed stereotactic localization of the internal segment of the globus pallidus …

We systematically evaluated the efficacy of both unilateral and bilateral stereotactic
pallidotomy in eight patients with generalized dystonia. Six patients had a marked …