In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …

Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at
high spatial and temporal resolution. However, the utility of existing GEVIs has been limited …

We report the evolution of mScarlet3, a cysteine-free monomeric red fluorescent protein with
fast and complete maturation, as well as record brightness, quantum yield (75%) and …

Current techniques for monitoring GABA (γ-aminobutyric acid), the primary inhibitory
neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop …

Cells interpret a variety of signals through G-protein-coupled receptors (GPCRs) and
stimulate the generation of second messengers such as cyclic adenosine monophosphate …

Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating
new insulin-producing cells from other cell types is a major aim of regenerative medicine …

CRISPR/Cas9 technology of genome editing has greatly facilitated the targeted inactivation
of genes in vitro and in vivo in a wide range of organisms. In zebrafish, it allows the rapid …

The eye lens of vertebrates is composed of fibre cells in which all membrane-bound
organelles undergo degradation during terminal differentiation to form an organelle-free …

Sequence-specific nucleases like TALENs and the CRISPR/Cas9 system have greatly
expanded the genome editing possibilities in model organisms such as zebrafish. Both …