As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Breast cancer is a complex disease, and several processes are involved in its development.
Therefore, potential therapeutic targets need to be discovered for these patients …

Increased activity of amino acid transporters has been observed in a wide variety of cancers.
However, whether amino acid metabolism is related to estrogen receptor-positive (ER+) …

The vascular endothelium is characterized by a remarkable level of plasticity, which is the
driving force not only of physiological repair/remodeling of adult tissues but also of …

The recent development of single-cell RNA sequencing has deepened our understanding of
the cell as a functional unit, providing new insights based on gene expression profiles of …

The cellular and molecular profiles that govern the endothelial heterogeneity of the
circulatory system have yet to be elucidated. Using a data-driven approach to study the …

Immune checkpoint blockade has recently proven effective in subsets of patients with
esophageal adenocarcinoma (EAC) but little is known regarding the EAC immune …

Triple-negative breast cancer (TNBC) is the most aggressive and deadly subtype of breast
cancer, accounting for 30,000 cases annually in the United States. While there are several …