Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …

Preconditioning influences mesenchymal stem cell properties in vitro and in vivo

C Hu, L Li - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Various diseases and toxic factors easily impair cellular and organic functions in mammals.
Organ transplantation is used to rescue organ function, but is limited by scarce resources …

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy

D García-Bernal, M García-Arranz… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) currently constitute the most frequently used cell type in
advanced therapies with different purposes, most of which are related with inflammatory …

Current strategies to enhance adipose stem cell function: an update

Y Seo, TH Shin, HS Kim - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) emerged as a promising therapeutic tool targeting a variety
of inflammatory disorders due to their multiple remarkable properties, such as superior …

Therapies for type 1 diabetes: current scenario and future perspectives

V Pathak, NM Pathak, CL O'Neill… - Clinical Medicine …, 2019 - journals.sagepub.com
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells
located in the endocrine pancreas in areas known as islets of Langerhans. The current …

Injectable hypoxia-induced conductive hydrogel to promote diabetic wound healing

X Jin, Y Shang, Y Zou, M Xiao, H Huang… - … Applied Materials & …, 2020 - ACS Publications
Injectable hydrogels with the capability to cast a hypoxic microenvironment is of great
potentialities to develop novel therapies for tissue regeneration. However, the relative …

Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats

N Ishiuchi, A Nakashima, S Doi, K Yoshida… - Stem cell research & …, 2020 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have been reported to promote the
regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic …

Bioprintable lung extracellular matrix hydrogel scaffolds for 3D culture of mesenchymal stromal cells

B Falcones, H Sanz-Fraile, E Marhuenda, I Mendizábal… - Polymers, 2021 - mdpi.com
Mesenchymal stromal cell (MSC)-based cell therapy in acute respiratory diseases is based
on MSC secretion of paracrine factors. Several strategies have proposed to improve this are …

Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells

A Gamble, R Pawlick, AR Pepper, A Bruni, A Adesida… - PloS one, 2018 - journals.plos.org
Islet transplantation is an established clinical procedure for select patients with type 1
diabetes and severe hypoglycemia to stabilize glycemic control. Post-transplant, substantial …