Gut barrier disruption and chronic disease

J Martel, SH Chang, YF Ko, TL Hwang… - Trends in Endocrinology …, 2022 - cell.com
The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

Effects and mechanisms of probiotics, prebiotics, synbiotics, and postbiotics on metabolic diseases targeting gut microbiota: A narrative review

HY Li, DD Zhou, RY Gan, SY Huang, CN Zhao… - Nutrients, 2021 - mdpi.com
Metabolic diseases are serious threats to public health and related to gut microbiota.
Probiotics, prebiotics, synbiotics, and postbiotics (PPSP) are powerful regulators of gut …

The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies

L Zitvogel, Y Ma, D Raoult, G Kroemer, TF Gajewski - Science, 2018 - science.org
The fine line between human health and disease can be driven by the interplay between
host and microbial factors. This “metagenome” regulates cancer initiation, progression, and …

Gut microbiota and cardiovascular disease: opportunities and challenges

N Kazemian, M Mahmoudi, F Halperin, JC Wu… - Microbiome, 2020 - Springer
Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised …

H Koutnikova, B Genser, M Monteiro-Sepulveda… - BMJ open, 2019 - bmjopen.bmj.com
Objective To systematically review the effect of oral intake of bacterial probiotics on 15
variables related to obesity, diabetes and non-alcoholic fatty liver disease. Design …

Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: a meta-analysis of randomized clinical trials

T Kocsis, B Molnár, D Németh, P Hegyi, Z Szakács… - Scientific reports, 2020 - nature.com
Probiotics have been reported to have a positive impact on the metabolic control of patients
with type 2 diabetes. We aimed to systematically evaluate the effects of probiotics on …

The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta-analysis

PM Bock, GH Telo, R Ramalho, M Sbaraini, G Leivas… - Diabetologia, 2021 - Springer
Aims/hypothesis The aim was to conduct a systematic review and meta-analysis of
randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic …

Treatment strategies against diabetes: Success so far and challenges ahead

R Khursheed, SK Singh, S Wadhwa, B Kapoor… - European journal of …, 2019 - Elsevier
The growing disease burden of diabetes mellitus is an important public health concern,
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …

Effects of synbiotic supplementation on chronic inflammation and the gut microbiota in obese patients with type 2 diabetes mellitus: a randomized controlled study

A Kanazawa, M Aida, Y Yoshida, H Kaga, T Katahira… - Nutrients, 2021 - mdpi.com
The aim of this study was to investigate the effects of 24-week synbiotic supplementation on
chronic inflammation and the gut microbiota in obese patients with type 2 diabetes. We …

Gut microbiome and its impact on obesity and obesity-related disorders

S Sankararaman, K Noriega, S Velayuthan… - Current …, 2023 - Springer
Abstract Purpose of Review The prevalence of overweight and obesity has been increasing
worldwide at an alarming rate. Gut microbiota intimately influence host energy metabolism …