Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic
acids with an interesting array of biological activities; eg, antioxidant, anti-inflammatory …

Hydroxycinnamates are among the most widely distributed plant phenylpropanoids present
in the free, conjugated-soluble and insoluble-bound forms. This review will focus on the …

Cardiovascular diseases are one of the leading causes of mortality in developed countries.
Among cardiovascular disorders, myocardial infarction remains a life-threatening problem …

Complementary and alternative medicine (CAM) has become increasingly popular in the
United States during the last 10–15 years. The use of oral and topical supplements falls …

Ischaemia–reperfusion injury is the mechanism underlying (partial) flap loss. This is not only
a traumatic event for the patient, it also causes increased patient morbidity [Kerrigan CL …

Prophylactic mastectomy is an effective risk-reducing option in women with hereditary
increased risk of breast cancer. It may be combined with immediate reconstruction, with the …

Skin flaps are frequently employed in plastic and reconstructive surgery to address tissue
defects. However, their low survival rates remain a challenge, attributed to vascular crisis …

BACKGROUND: We recently established negative pressure wound therapy (NPWT) as a
safe postoperative care concept for free muscle flaps; however, the molecular effects of …

Background: Ischemia-reperfusion (I/R) injury is a leading cause of surgical skin flap
compromise and organ dysfunction. Platelet-rich plasma (PRP) is an abundant reserve of …

Aims In pressure ulcers, the synthesis of reactive oxygen species induced by ischemia and
reperfusion leads to chronic inflammation and tissue damage, which impair the closure of …