[HTML][HTML] Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR
H Schuhwerk, T Brabletz - Seminars in Cancer Biology, 2023 - Elsevier
TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …
Key molecular DNA damage responses of human cells to radiation
C Zhang, J Liu, J Wu, K Ranjan, X Cui… - Frontiers in Cell and …, 2024 - frontiersin.org
Our understanding of the DNA damage responses of human cells to radiation has increased
remarkably over the recent years although some notable signaling events remain to be …
remarkably over the recent years although some notable signaling events remain to be …
DNA damage–induced EMT controlled by the PARP-dependent chromatin remodeler ALC1 promotes DNA repair efficiency through RAD51 in tumor cells
Epithelial-to-mesenchymal transition (EMT) allows cancer cells to metastasize while
acquiring resistance to apoptosis and chemotherapeutic agents with significant implications …
acquiring resistance to apoptosis and chemotherapeutic agents with significant implications …
[HTML][HTML] Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction
H Zhou, Z Xu, C Jiang, Q Wu… - Cell …, 2025 - biosignaling.biomedcentral.com
Ionizing radiation (IR) poses a significant threat to male fertility by inducing substantial
changes in the testis, yet the mechanisms underlying IR-induced spermatogenesis disorders …
changes in the testis, yet the mechanisms underlying IR-induced spermatogenesis disorders …
Mitochondrial genome-encoded mitomiRs regulate cellular plasticity and susceptibility to ferroptosis in triple-negative breast cancer
A Kandettu, J Ghosal, JS Tharayil, R Kuthethur… - bioRxiv, 2024 - biorxiv.org
Ferroptosis is a distinct form of regulated cell death promoted by iron-dependent lipid
peroxidation. The metabolic plasticity of cancer cells determines their sensitivity to …
peroxidation. The metabolic plasticity of cancer cells determines their sensitivity to …