Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many
patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based …

The hallmarks of stem cells, such as proliferation, self-renewal, development, differentiation,
and regeneration, are critical to maintain stem cell identity which is sustained by genetic and …

With the development of sequencing technology and the dramatic drop in sequencing cost,
the functions of noncoding genes are being characterized in a wide variety of fields (eg …

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to
induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert …

For more than a century, formalin-fixed paraffin-embedded (FFPE) sample preparation has
been the preferred method for long-term preservation of biological material. However, the …

Dysfunctional gene expression in nociceptive pathways plays a critical role in the
development and maintenance of neuropathic pain. Super enhancers (SEs), composed of a …

The majority of biopsies in both basic research and translational cancer studies are
preserved in the format of archived formalin-fixed paraffin-embedded (FFPE) samples …

Large-scale high-dimensional multiomics studies are essential to unravel molecular
complexity in health and disease. We developed an integrated system for tissue sampling …

Cancer cells accumulate epigenomic aberrations that contribute to cancer initiation and
progression by altering both the genomic stability and the expression of genes. The …

Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant syndrome caused
by inactivating pathogenic variants in the tumor suppressor gene menin 1 on chromosome …