Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

Alternative Splicing (AS) programs serve as instructive signals of cell type specificity,
particularly within the brain, which comprises dozens of molecularly and functionally distinct …

Many molecular mechanisms underlying blood glucose homeostasis remain elusive. Juan-
Mateu et al. find that pancreatic islet cells utilize a regulatory program, originally identified in …

Abstract FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering
transcription factors that build gene expression capacity and play a central role in biological …

Disruptions in spatiotemporal gene expression can result in atypical brain function.
Specifically, autism spectrum disorder (ASD) is characterized by abnormalities in pre‐mRNA …

Functional microexons have not previously been described in filamentous fungi. Here, we
describe a novel mechanism of transcriptional regulation in Trichoderma requiring the …

BACKGROUND Patients with type 2 diabetes mellitus (T2DM) have large fluctuations in
blood glucose (BG), abnormal metabolic function and low immunity to varying degrees …

Recent estimations suggest that approximately 1.5 billion people around the world are
suffering from a chronic liver condition associated to diverse etiopathological agents1 …

Altered splicing is a frequent mechanism by which genetic variants cause disease and
antisense oligonucleotides (AONs) that target pre-mRNA splicing have been approved as …

Microexons are essential for proper functioning of neurons and pancreatic endocrine cells,
where their inclusion depends on the splicing factors SRRM3/4. However, in pancreatic …