Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

A quintessential sentinel of cell health, the membrane potential in nonexcitable cells
integrates biochemical and biomechanical inputs, determines the driving force for ionic …

Force sensing is a fundamental ability that allows cells and organisms to interact with their
physical environment. The eye is constantly subjected to mechanical forces such as blinking …

Baseline intracellular calcium levels are significantly higher in neuronal and glial cells of rat
retinas with retinitis pigmentosa (RP). Although this situation could initiate multiple …

Purpose: To identify the expression of the mechanosensitive ion channel Piezo1 in the
retina of guinea pigs with form deprivation myopia (FDM) and to investigate mechanisms by …

The architecture of the vertebrate eye is optimized for efficient delivery and transduction of
photons and processing of signaling cascades downstream from phototransduction. The …

Background Glaucoma, a progressive neurodegenerative disease, is a leading cause of
irreversible vision loss worldwide. This study aims to elucidate the critical role of Müller glia …

Alterations in intraocular and external pressure critically involve the pathogenesis of
glaucoma, traumatic retinal injury (TRI), and other retinal disorders, and retinal neurons …