MHC class I molecules are peptide receptors of stringent specificity which however still allow
millions of different ligands. This is achieved by the following specificity characteristics …

The crystal structures of major histocompatibility complex (MHC) molecules contain a groove
occupied by heterogeneous material thought to represent peptides central to immune …

Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift),
and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain …

THE testis-determining factor gene (TDF) lies on the Y chromosome and is responsible for
initiating male sex determination. SRY is a gene located in the sex-determining region of the …

We reported previously that human gene MAGE-1 directs the expression of a tumor antigen
recognized on a melanoma by autologous cytolytic T lymphocytes. Probing cosmid libraries …

VIRUS-infected cells can be eliminated by cytotoxic T lymphocytes (CTL), which recognize
virus-derived peptides bound to major histocompatibility complex (MHC) class I molecules …

Abstract CYTOTOXIC T lymphocytes (CTL) constitute an essential part of the immune
response against viral infections1. Such CTL recognize peptides derived from viral proteins …

We describe a cell in which association of a major histocompatibility complex class I heavy
chain with β2-microglobulin is induced by a peptide derived from influenza nucleoprotein …

Using an approach for isolating and characterizing peptide fractions that are intracellularly
associated with major histocompatibility complex class I molecules, the major peptide …

An analysis of the known cytotoxic and helper T cell epitopes has revealed similarity within
their primary sequences. These similar motifs, characteristic of the known determinants …