Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

Amorphous solid dispersion (ASD) formulations are widely used for delivery of poorly
soluble drugs for dissolution enhancement and bioavailability improvement. When …

Crystallization is one of the oldest separation and purification unit operations, and has
recently contributed to significant improvements in producing higher-value products with …

Enzalutamide is a fast crystallizing, hydrophobic compound that has solubility limited
absorption in vivo. Given the low aqueous solubility of this compound, it was of interest to …

Formulating poorly soluble molecules as amorphous solid dispersions (ASDs) is an effective
strategy to improve drug release. However, drug release rate and extent tend to rapidly …

High drug load amorphous solid dispersions (ASDs) have been a challenge to formulate
partially because drug release is inhibited at high drug loads. The maximum drug load prior …

Dissolution of amorphous solid dispersions (ASD) can lead to the formation of amorphous
drug-rich nano species (nanodroplets) via liquid–liquid phase separation or glass–liquid …

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the
fabrication of most dosage forms, irrespective of the administration route. They play various …

The generation of a colloidal drug-rich phase by dissolving an amorphous solid dispersion
(ASD) is thought to have a positive impact on oral absorption and bioavailability. Thus …

Over the last few decades, polymers have been extensively used as pharmaceutical
excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply …