Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …

The application of immunotherapy for cancer treatment is rapidly becoming more
widespread. Immunotherapeutic agents are frequently combined with various types of …

Despite prevention and treatment options, breast cancer (BC) has become one of the most
important issues in the present day. Therefore, the need for more specific and efficient …

The ataxia telangiectasia mutated serine/threonine kinase (ATM)/checkpoint kinase 2
(CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase …

In order to efficiently characterize both antiproliferative potency and mechanism of action of
small molecules targeting the cell cycle, we developed a high-throughput image-based …

Etoposide is a broadly employed chemotherapeutic and eukaryotic topoisomerase II poison
that stabilizes cleaved DNA intermediates to promote DNA breakage and cytotoxicity. How …

In Epstein–Barr Virus infected epithelial cancers, the alternatively spliced BamHI A rightward
transcripts (BARTs) are abundantly expressed and are the template for two large clusters of …

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer
cells often display centrosome amplification. To maintain survival, cancer cells achieve …

Severe sepsis remains a poorly understood systemic inflammatory condition with high
mortality rates and limited therapeutic options in addition to organ support measures. Here …

In addition to allelic mutations, cancers are known to harbor alterations in their chromatin
landscape. Here we show that genomic ablation of Smad ubiquitin regulatory factor 2 …